BDBM50008923 (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione::(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin)::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin)::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT)::4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione::CHEMBL65::Camptothecin (CT)::camptothecine::cid_24360
SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
InChI Key InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 50008923
Affinity DataIC50: 224nMAssay Description:Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibitory activity against DNA topoisomerase-I obtained from Hela cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 679nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
Affinity DataEC50: 350nMAssay Description:Effective concentration against DNA topoisomerase IMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Ability of the compound to satbilize DNA-topoisomerase (from calf) I-compound ternary complex was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formationMore data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant DNA topoisomerase1More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) VACO 241 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.75E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium brom...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human Top1 expressed in baculovirus infected sf9 insect cells using supercoiled pBS (SK+) DNA as substrate incubated for 30...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Top1 in human MCF7 cells using supercoiled pBS (SK+) DNA as substrate incubated for 30 mins by ethidium bromide staining based agarose ...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of human topoisomerase-1 beta incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.29E+4nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of human topoisomerase I assessed as DNA relaxation using DNA pBR322 as substrate incubated for 30 mins by ethidium bromide staining based...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 assessed as reduction in pBR322 DNA relaxation incubated for 1 hrs measured by agarose gel electrophoresis me...More data for this Ligand-Target Pair